Depth distributions of RBE-weighted dose and photon-isoeffective dose for boron neutron capture therapy

Sato, Tatsuhiko; Masunaga, Shinichiro*; Kumada, Hiroaki*; Hamada, Nobuyuki*

Radiation Protection Dosimetry, 183(1-2), p.247 - 250, 2019/05

https://doi.org/10.1093/rpd/ncy235

As an application of Particle and Heavy Ion Transport code System PHITS, We have developed the stochastic microdosimetric kinetic (SMK) model for estimating the therapeutic effects of various kinds of radiation therapy. In this study, we improved the SMK model for estimating the therapeutic effect of boron neutron capture therapy, BNCT. The improved SMK model can consider not only the intra- and intercellular heterogeneity of B-10 distribution but also the dose rate effect. The accuracy of the model was well verified by comparisons made between calculated and measured surviving fractions of tumor cells, which we previously determined in vivo in mice with B-10 compounds exposed to reactor neutron beam. Details of the improved SMK model together with the verification results will be presented at the meeting.